Molecularly Imprinted Polymers
Molecularly Imprinted Polymers (MIPs) are crosslinked polymer networks capable of specifically binding a target molecule. As such, they are also often called “synthetic antibodies”.
The basic synthetic steps consist of the following:
(1) Polymerization of different monomers and a crosslinker in presence of a template molecule to form polymeric particles around the template
(2) Removal of the target molecule, which leaves specific binding cavities within the polymer network ready for rebinding the template